Modern Management of Benign Bile Duct Strictures

نویسندگان

  • Cristian Balahura
  • Petre Iacob Calistru
  • Gabriel Constantinescu
چکیده

The diagnosis and treatment of benign biliary strictures (BBS) are often challenging. In the past, surgery was the treatment of choice in the majority of cases. Nowadays the endoscopic treatment of BBS is preferred over surgery because it is less invasive, repeatable and associated with lower morbidity rates. The endoscopic retrograde cholangiopancreatography (ERCP) can make the diagnosis of the stricture, and provide its dilation and stent placement. Temporary insertion of multiple side-by-side large-bore plastic stent is the standard of care in endoscopic therapy. The use of uncovered self-expanding metal stents is under investigation. Most commonly BBS occur in the evolution of chronic pancreatitis, and after liver transplant or cholecystectomy. The efficacy of endoscopic therapies is different and depends on the cause of BBS. Though it has limitations, endoscopic therapy has a favourable safety profile and remains a first-line management option in benign biliary strictures. REZUMAT Managementul modern al stenozelor biliare benigne Stenozele biliare benigne reprezintã o patologie cu abordare diagnosticã æi terapeuticã deseori dificilã. În trecut principalul tratament în majoritatea cazurilor era chirurgical. Astãzi terapia endoscopicã este preferatã având în vedere cã este minim invazivã, poate fi repetatã æi are rate reduse de morbiditate. Colangiografia endoscopicã retrogradã (ERCP) este utilã pentru stabilirea diagnosticului æi realizarea dilatãrii æi stentãrii stenozei. Inseråia temporarã de stenturi biliare de plastic multiple reprezintã tratamentul endoscopic standard. Eficienåa utilizãrii stenturilor biliare metalice expandabile neacoperite este în curs de evaluare. Majoritatea stenozelor biliare benigne apar în evoluåia pancreatitei cronice, dupã colecistectomie sau dupã transplant hepatic. Rezultatele terapiei endoscopice diferã în funcåie de etiologia stenozei. Deæi nu este eficient în toate cazurile, tratamentul endoscopic are un profil de siguranåã acceptabil æi este prima linie de abordare a stenozelor biliare benigne. El poate fi util ca “punte” cãtre tratamentul chirurgical în unele cazuri de pancreatitã cronicã sau stenoze post-transplant hepatic. Cuvinte cheie: stenoze biliare, ERCP, pancreatitã cronicã, colecistectomie, transplant hepatic Modern Medicine. 2015, Vol. 22, No. 2 : 144Copyright© Celsius

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تاریخ انتشار 2015